344 research outputs found

    There\u27s No Stopping Us Now! Why Systematic Staff Training Keeps the Organization Moving Forward

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    Libraries have shifted from repositories of materials to centers of innovation and community-based learning. Many library services changed to accommodate the shift; some staff find this difficult and perplexing and it has led to technological wariness and resistance to change. To address this we developed a continuous in-house professional development program. We will discuss barriers and enablers to establishing a program and unintended benefits, such as reducing perceived inequalities among staff, increasing trust, and empowering staff

    Exercise Training and Functional Connectivity Changes in Mild Cognitive Empairment and Healthy Elders

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    Background: Effective interventions are needed to improve brain function in mild cognitive impairment (MCI), an early stage of Alzheimer’s disease (AD). The posterior cingulate cortex (PCC)/precuneus is a hub of the default mode network (DMN) and is preferentially vulnerable to disruption of functional connectivity in MCI and AD. Objective: We investigated whether 12 weeks of aerobic exercise could enhance functional connectivity of the PCC/precuneus in MCI and healthy elders. Methods: Sixteen MCI and 16 healthy elders (age range = 60–88) engaged in a supervised 12-week walking exercise intervention. Functional MRI was acquired at rest; the PCC/precuneus was used as a seed for correlated brain activity maps. Results: A linear mixed effects model revealed a significant interaction in the right parietal lobe: the MCI group showed increased connectivity while the healthy elders showed decreased connectivity. In addition, both groups showed increased connectivity with the left postcentral gyrus. Comparing pre to post intervention changes within each group, the MCI group showed increased connectivity in 10 regions spanning frontal, parietal, temporal and insular lobes, and the cerebellum. Healthy elders did not demonstrate any significant connectivity changes. Conclusion: The observed results show increased functional connectivity of the PCC/precuneus in individuals with MCI after 12 weeks of moderate intensity walking exercise training. The protective effects of exercise training on cognition may be realized through the enhancement of neural recruitment mechanisms, which may possibly increase cognitive reserve. Whether these effects of exercise training may delay further cognitive decline in patients diagnosed with MCI remains to be demonstrated

    Improved Cardiorespiratory Fitness Is Associated with Increased Cortical Thickness in Mild Cognitive Impairment

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    Cortical atrophy is a biomarker of Alzheimer’s disease (AD) that correlates with clinical symptoms. This study examined changes in cortical thickness from before to after an exercise intervention in mild cognitive impairment (MCI) and healthy elders. Thirty physically inactive older adults (14 MCI, 16 healthy controls) underwent MRI before and after participating in a 12-week moderate intensity walking intervention. Participants were between the ages of 61 and 88. Change in cardiorespiratory fitness was assessed using residualized scores of the peak rate of oxygen consumption (V̇O2peak) from pre- to post-intervention. Structural magnetic resonance images were processed using FreeSurfer v5.1.0. V̇O2peak increased an average of 8.49%, which was comparable between MCI and healthy elders. Overall, cortical thickness was stable except for a significant decrease in the right fusiform gyrus in both groups. However, improvement in cardiorespiratory fitness due to the intervention (V̇O2peak) was positively correlated with cortical thickness change in the bilateral insula, precentral gyri, precuneus, posterior cingulate, and inferior and superior frontal cortices. Moreover, MCI participants exhibited stronger positive correlations compared to healthy elders in the left insula and superior temporal gyrus. A 12-week moderate intensity walking intervention led to significantly improved fitness in both MCI and healthy elders. Improved V̇O2peak was associated with widespread increased cortical thickness, which was similar between MCI and healthy elders. Thus, regular exercise may be an especially beneficial intervention to counteract cortical atrophy in all risk groups, and may provide protection against future cognitive decline in both healthy elders and MCI

    Tracing the Origins and Evolution of Small Planets using Their Orbital Obliquities

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    We recommend an intensive effort to survey and understand the obliquity distribution of small close-in extrasolar planets over the coming decade. The orbital obliquities of exoplanets--i.e., the relative orientation between the planetary orbit and the stellar rotation--is a key tracer of how planets form and migrate. While the orbital obliquities of smaller planets are poorly explored today, a new generation of facilities coming online over the next decade will make such observations possible en masse. Transit spectroscopic observations with the extremely large telescopes will enable us to measure the orbital obliquities of planets as small as 2R\sim2R_{\oplus} around a wide variety of stars, opening a window into the orbital properties of the most common types of planets. This effort will directly contribute to understanding the formation and evolution of planetary systems, a key objective of the National Academy of Sciences' Exoplanet Science Strategies report.Comment: Submitted to the Astro2020 call for science white papers. 7 pages, 2 figure

    Astro2020 Science White Paper: Toward Finding Earth 2.0: Masses and Orbits of Small Planets with Extreme Radial Velocity Precision

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    Having discovered that Earth-sized planets are common, we are now embarking on a journey to determine if Earth-like planets are also common. Finding Earth-like planets is one of the most compelling endeavors of the 21st century - leading us toward finally answering the question: Are we alone? To achieve this forward-looking goal, we must determine the masses of the planets; the sizes of the planets, by themselves, are not sufficient for the determination of the bulk and atmospheric compositions. Masses, coupled with the radii, are crucial constraints on the bulk composition and interior structure of the planets and the composition of their atmospheres, including the search for biosignatures. Precision radial velocity is the most viable technique for providing essential mass and orbit information for spectroscopy of other Earths. The development of high quality precision radial velocity instruments coupled to the building of the large telescope facilities like TMT and GMT or space-based platforms like EarthFinder can enable very high spectral resolution observations with extremely precise radial velocities on minute timescales to allow for the modeling and removal of radial velocity jitter. Over the next decade, the legacy of exoplanet astrophysics can be cemented firmly as part of humankind's quest in finding the next Earth - but only if we can measure the masses and orbits of Earth-sized planets in habitable zone orbits around Sun-like stars.Comment: Science White Paper Submitted to the Astro2020 Decadal Survey (35 co-signers in addition to co-authors

    Long-Period Giant Companions to Three Compact, Multiplanet Systems

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    Understanding the relationship between long-period giant planets and multiple smaller short-period planets is critical for formulating a complete picture of planet formation. This work characterizes three such systems. We present Kepler-65, a system with an eccentric (e = 0.28 ± 0.07) giant planet companion discovered via radial velocities (RVs) exterior to a compact, multiply transiting system of sub-Neptune planets. We also use precision RVs to improve mass and radius constraints on two other systems with similar architectures, Kepler-25 and Kepler-68. In Kepler-68 we propose a second exterior giant planet candidate. Finally, we consider the implications of these systems for planet formation models, particularly that the moderate eccentricity in Kepler-65\u27s exterior giant planet did not disrupt its inner system

    Resting Cerebral Blood Flow After Exercise Training in Mild Cognitive Impairment

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    Background: Exercise training has been associated with greater cerebral blood flow (CBF) in cognitively normal older adults (CN). Alterations in CBF, including compensatory perfusion in the prefrontal cortex, may facilitate changes to the brain’s neural infrastructure. Objective: To examine the effects of a 12-week aerobic exercise intervention on resting CBF and cognition in CN and those with mild cognitive impairment (MCI). We hypothesized individuals with MCI (vs. CN) would exhibit greater whole brain CBF at baseline and that exercise would mitigate these differences. We also expected CBF changes to parallel cognitive improvements. Methods: Before and after a 12-week exercise intervention, 18 CN and 17 MCI participants (aged 61–88) underwent aerobic fitness testing, neuropsychological assessment, and an MRI scan. Perfusion-weighted images were collected using a GE 3T MR system. Repeated measures analyses of covariance were used to test within- and between-group differences over time, followed by post-hoc analyses to examine links between CBF changes and cognitive improvement. Results: At baseline, individuals with MCI (vs. CN) exhibited significantly elevated perfusion in the left insula. Twelve weeks of aerobic exercise reversed this discrepancy. Additionally, exercise improved working memory (measured by the Rey Auditory Verbal Learning Test) and verbal fluency (measured by the Controlled Oral Word Association Test) and differentially altered CBF depending on cognitive status. Among those with MCI, decreased CBF in the left insula and anterior cingulate cortex was associated with improved verbal fluency. Conclusions: Exercise training alters CBF and improves cognitive performance in older adults with and without cognitive impairment. Future studies must evaluate the mediating effects of CBF on the association between exercise training and cognition

    Discovery of a White Dwarf Companion to HD 159062

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    We report on the discovery of a white dwarf companion to the nearby late G dwarf star, HD 159062. The companion is detected in 14 years of precise radial velocity (RV) data, and in high-resolution imaging observations. RVs of HD 159062 from 2003-2018 reveal an acceleration of 13.3±0.12 ms1-13.3\pm0.12\ \rm{m s}^{-1}, indicating that it hosts a companion with a long-period orbit. Subsequent imaging observations with the ShaneAO system on the Lick Observatory 3-meter Shane telescope, the PHARO AO system on the Palomar Observatory 5-meter telescope, and the NIRC2 AO system at the Keck II 10-meter telescope reveal a faint companion 2.7'' from the primary star. We performed relative photometry, finding ΔJ=10.09±0.38\Delta J = 10.09 \pm 0.38 magnitudes, ΔKS=10.06±0.22\Delta K_{S} = 10.06 \pm 0.22 magnitudes, and ΔL=9.67±0.08\Delta L' = 9.67\pm0.08 magnitudes for the companion from these observations. Analysis of the radial velocities, astrometry, and photometry reveals that the combined data set can only be reconciled for the scenario where HD 159062 B is a white dwarf. A full Bayesian analysis of the RV and imaging data to obtain the cooling age, mass, and orbital parameters of the white dwarf indicates that the companion is an old MB=0.650.04+0.12MM_{B} = 0.65^{+0.12}_{-0.04} M_{\odot} white dwarf with an orbital period of P=25076+130P = 250^{+130}_{-76} years, and a cooling age of τ=8.20.5+0.3\tau = 8.2^{+0.3}_{-0.5} Gyr.Comment: 10 pages, 9 figure

    HAT-P-11: Discovery of a Second Planet and a Clue to Understanding Exoplanet Obliquities

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    HAT-P-11 is a mid-K dwarf that hosts one of the first Neptune-sized planets found outside the solar system. The orbit of HAT-P-11b is misaligned with the star's spin --- one of the few known cases of a misaligned planet orbiting a star less massive than the Sun. We find an additional planet in the system based on a decade of precision radial velocity (RV) measurements from Keck/HIRES. HAT-P-11c is similar to Jupiter in its mass (MPsini=1.6±0.1M_P \sin{i} = 1.6\pm0.1 MJM_J) and orbital period (P=9.30.5+1.0P = 9.3^{+1.0}_{-0.5} year), but has a much more eccentric orbit (e=0.60±0.03e=0.60\pm0.03). In our joint modeling of RV and stellar activity, we found an activity-induced RV signal of \sim7 m s1^{-1}, consistent with other active K dwarfs, but significantly smaller than the 31 m s1^{-1} reflex motion due to HAT-P-11c. We investigated the dynamical coupling between HAT-P-11b and c as a possible explanation for HAT-P-11b's misaligned orbit, finding that planet-planet Kozai interactions cannot tilt planet b's orbit due to general relativistic precession; however, nodal precession operating on million year timescales is a viable mechanism to explain HAT-P-11b's high obliquity. This leaves open the question of why HAT-P-11c may have such a tilted orbit. At a distance of 38 pc, the HAT-P-11 system offers rich opportunities for further exoplanet characterization through astrometry and direct imaging.Comment: 16 pages, 11 figures, 4 tables. Accepted to A
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